Suicidal Membrane Repair Regulates Phosphatidylserine Externalization during Apoptosis
نویسندگان
چکیده
منابع مشابه
Suicidal membrane repair regulates phosphatidylserine externalization during apoptosis.
One of the hallmarks of apoptosis is the redistribution of phosphatidylserine (PS) from the inner-to-outer plasma membrane (PM) leaflet, where it functions as a ligand for phagocyte recognition and the suppression of inflammatory responses. The mechanism by which apoptotic cells externalize PS has been assumed to involve "scramblases" that randomize phospholipids across the PM bilayer. These pu...
متن کاملPhospholipid signaling in apoptosis: peroxidation and externalization of phosphatidylserine.
The role of phospholipids in apoptosis signaling and the relationship between oxidation of phosphatidylserine and its redistribution in the plasma membrane were studied. A novel method for detection of site-specific phospholipid peroxidation based on the use of cis-parinaric acid as a reporter molecule metabolically integrated into membrane phospholipids in living cells was employed. When sever...
متن کاملNADPH Oxidase-dependent Oxidation and Externalization of Phosphatidylserine during Apoptosis in Me2SO-differentiated HL-60 Cells
From the Department of Environmental and Occupational Health, Department of Pharmacology, and Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, the Magee-Womens Research Institute, Pittsburgh, Pennsylvania 15213, the Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia, the Department of Medical Ch...
متن کاملPhosphatidylserine externalization, “necroptotic bodies” release, and phagocytosis during necroptosis
Necroptosis is a regulated, nonapoptotic form of cell death initiated by receptor-interacting protein kinase-3 (RIPK3) and mixed lineage kinase domain-like (MLKL) proteins. It is considered to be a form of regulated necrosis, and, by lacking the "find me" and "eat me" signals that are a feature of apoptosis, necroptosis is considered to be inflammatory. One such "eat me" signal observed during ...
متن کاملPhosphatidylserine externalization in human sperm induced by calcium ionophore A23187: relationship with apoptosis, membrane scrambling and the acrosome reaction.
BACKGROUND Translocation of phosphatidylserine (PS) from the inner to the outer leaflet of the plasma membrane is a modification of the lipid architecture occurring in sperm. This is one of the earliest signs of apoptosis that can be monitored by the calcium-dependent binding of annexin V. METHODS AND RESULTS Flow cytometric analysis of annexin V binding was performed. Calcium ionophore A2318...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2009
ISSN: 0021-9258
DOI: 10.1074/jbc.c109.022913